Summary
Patent Pending CONOCB2™ is powerful, drug-free pain relief support. Currently, it is the only natural “Conolidine” ingredient available in the world. It is a science backed, phytochemical-rich proprietary blend that can be legally sold across the globe and legally consumed by drug-tested (WADA) athletes. This product is a combination of naturally occurring herbal compounds including Tabernaemontana divaricata (Crepe Jasmine), Palmitoylethanolamide (PEA), and Piperine (Black Pepper Extract 95%) meant to support your body’s ability to target and reduce mild to chronic pain and inflammation. These powerful ingredients are blended together using our patent pending, proprietary extraction method. CONOCB2™ ‘s safe, potent and natural ingredients, have no reported or suspected side effects such as those that are commonly attributed to over-the-counter and opioid based, synthetic pain relievers. CONOCB2™ is a liquid proprietary blend that can be utilized across multiple Cosmetic, Supplemental (Dietary) and even Over-The-Counter (OTC) applications.
What is Conolidine
Conolidine is widely considered one of the greatest pain relief discoveries in the last 20 years. It is one of the 66 alkaloids found in the Tabernaemontana divaricata (Crepe Jasmine) plant; generally from the bark and root of the plant.
Conolidine has been tested extensively as a pain reliever and has been compared in efficacy to more traditional, opiate-derived pain medications like morphine. Early scientific opinion surmises that Conolidine is the first known alkaloid to clear the “Scavenger” receptors in your brain, potentially allowing for your body’s natural endorphins to be fully optimized and regulated; a true first of its kind.
1 In addition to being the first endorphin-optimizing ingredient, studies indicate that each constituent of CONOCB2™ possesses none of the detrimental side effects associated with conventional over-the-counter and pharmaceutical prescription pain relief products.
How It Works
CONOCB2™ works on multiple functions of the brain and body. Tabernaemontana divaricata (Crepe Jasmine), which contains the Conolidine alkaloid, works on a fairly recently discovered opioid receptor named ACKR3/CXCR7 and regulates naturally produced opioid peptides in the brain.2
What does that mean? This means that the body’s naturally produced painkillers (opioid peptides) are more capable of reaching your brain’s opioid receptors instead of being “scavenged.” Conolidine essentially creates a barrier between the “Scavenger” Receptors and Opioid Receptors, allowing your body’s ability to deliver its own endorphins to be fully optimized. In addition to the Crepe Jasmine, the Palmitoylethanolamide (PEA) targets alpha peroxisome proliferator-activated receptors (PPAR-α) found on neurons in the brain that are naturally activated as a result of nerve damage, along with targeting cannabinoid receptors (CB1, CB2).3, 4
Conolidine also affects transient receptor potential vanilloid type-1 (TRPV1) ion channels which have been shown to compound the effects of the Crepe Jasmine and increase anti-inflammatory effects. Finally, the Piperine (Black Pepper Extract 95%) dramatically increases bioavailability, a common issue with Dietary Supplements and other medications. Most predominantly, Piperine has been shown to increase absorption in the GIT (gastro-intestinal tract) by inhibiting or inducing numerous enzymes including, but not limited to, CYP1A1, CYP1B1, CYP1B2, CYP2E1, CYP3A4 etc.5
Route of administration
Oral
When administered orally, CONOCB2™ will work into the body via the mucous membranes in the GI Tract, mouth and under the tongue (sublingual), travel to the brain and is able to pass through the blood-brain barrier due to the use of our proprietary extraction method used when producing CONOCB2™.
This method of delivery allows for relatively fast absorption of compounds that may not be generally as effective by standard GI ingestion.
Transdermal
When administered to the skin, CONOCB2™ has the ability to travel into the bloodstream as a result of the same solvents that make it so effective when Orally administered.
Containing industry leading, scientifically studied and natural solvents, transdermal application is achieved by reversibly decreasing barrier resistance in the skin. Additionally, the ethanolic effect allows the lipid barrier in the skin to be more easily penetrated.
Clinical Studies
- https://www.nature.com/articles/s41392-021-00548-w
- https://www.sciencedaily.com/releases/2021/06/210603171309.htm
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683964/
- https://pubmed.ncbi.nlm.nih.gov/25205418/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/
- https://academic.oup.com/painmedicine/article/13/9/1121/1864240
Why is CONOCB2™ unique?
CONOCB2™ is unique in the entirety of its approach, production and science. Completely novel, this ingredient is patent pending and unavailable anywhere else in the world. CONOCB2™ is able to attack pain from a safe, non-addictive and natural space unlike anything that has preceded it. This ingredient is the first known compound with the potential ability to completely optimize one’s own natural pain relief system without the negative effects of traditional pharmaceutical medications. CONOCB2™ is a completely drug-free alternative for the potential alleviation of general aches and pains along with severe chronic pain.6 CONOCB2™ is special from every angle of conception.
Ingredients
Tabernaemontana divaricata
full spectrum (Crepe Jasmine) liquid extract
Palmitoylethanolamide (PEA)
liquid extract
Piperine 95%
(Black Pepper Extract) Powder liquid extract
Conolidine CONOCB2™ Leverages the Entourage Effect:
The Entourage Effect is a fairly new concept that simply suggests that the sum of the whole is far more effective than its parts. For example, it could be argued that a standard hydrocodone pain pill containing 500mg of acetaminophen and 10mg of hydrocodone is far more effective than either the 500mg of acetaminophen or the 10mg of hydrocodone alone. In the case of CONOCB2™, the same approach is taken.
The addition of one compound that targets the opioid receptors (Conolidine), one that reduces nerve pain at the neuron level (PEA) and targeting both of them with an ingredient that enhances its bioavailability and deliverability (Piperine) along with delivering all of these compounds in a novel solution that has anti-inflammatory properties would be far more effective than any of the individual parts on their own.